News

The MedChem Lab Milestones

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  Federica Piaggi wins “Ing. Giacomo Bonaiuti” prize by Bracco Foundation
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  Patent selected to participate to the Meet in Italy for Life Sciences brokerage event
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  The registration for the 21st edition of the II level master in ‘Progettazione e Sviluppo dei Farmaci’ for the years 22-23 are OPEN!!!
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  Patent of the University of Pavia selected for the event Biovaria, Munich 8-9 May 2019

Congress and dissemination

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  Oral and Flash presentation contributions to 30th SCT- Young Research Fellows Meeting30 Gennaio 2023
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  Poster contribution to Proteine 202211 Ottobre 2022
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  Poster contribution to ESMEC (European School of Medicinal Chemistry)11 Ottobre 2022
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  Oral and poster contributions to PEVM2022 (Paul Ehrlich)11 Ottobre 2022
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  Dr Valeria Cavalloro received the prize awarded by Indena at the ISSNP International Summer School on Natural Products 4th Edition11 Ottobre 2022
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  Oral contribution to IX Workshop Gruppo Interdivisionale Green Chemistry – Chimica Sostenibile11 Ottobre 2022
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  Poster contribution to 27th National Meeting on Medicinal Chemistry11 Ottobre 2022
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  Oral contribution to SCI 2021 – XXVII Congresso Nazionale della Società Chimica Italiana11 Ottobre 2022
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  Dr Roberta Listro wins the prize for the best poster at PEVM2021 (Paul Ehrlich)11 Ottobre 2022
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  Poster contribution to NPCF 13 (Young medicinal chemist symposium)11 Ottobre 2022
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  Oral contribution to MYCS (Merck Young Chemists Symposium)11 Ottobre 2022
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  Poster contribution to ESMEC (European School of Medicinal Chemistry)11 Ottobre 2022

Publications

• Identification of a novel extracellular inhibitor of FGF2/FGFR signaling axis by combined Virtual Screening and NMR Spectroscopy approach
  Pagano, K.; Listro, R.;  Linciano, P.; Rossi, D.; Longhi, E.; Taraboletti, G.; Molinari, H.; Collina, S.; Ragona, L. (2023) Bioorganic Chemistry, 106529 DOI: 10.1016/j.bioorg.2023.106529 ABSTRACT: The aberrant activation of the fibroblast growth factor 2 (FGF2)/fibroblast growth factor receptor (FGFR) signalling pathway drives severe pathologies, including cancer development and angiogenesis-driven pathologies. The perturbation of the FGF2/FGFR axis via extracellular
• Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
  Alfano, A.I.; Pelliccia, S.; Rossino, G.; Chianese, O.; Summa, V.; Collina, S.; Brindisi, M. (2023) ACS Med. Chem. Lett.14(3), 326–337 DOI: 10.1021/acsmedchemlett.3c00010 ABSTRACT: The efficacy, safety, and scale-up of several chemical rearrangements remain unsolved problems due to the associated handling of hazardous, toxic, and pollutant chemicals and high-risk intermediates. For many years batch processes have been considered the only possibility to drive
• Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
  Alfano, A.I.; Pelliccia, S.; Rossino, G.; Chianese, O.; Summa, V.; Collina, S.; Brindisi M. (2023) ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.3c00072 In recent years, photochemistry has increasingly emerged as an enabling methodology in both academia and the pharmaceutical industry. Long photolysis times and the gradual reduction of light penetration remained for many years unsolved issues for photochemical rearrangements,
• Structural Insights into the Ligand–LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents
  Listro, R.; Milli, G.; Pellegrini, A.; Motta, C.; Cavalloro, V.; Martino, E.; Kirchmair, J.; Pietrocola, G.; Rossi, D.; Linciano, P.; Collina, S. (2023) Molecules, 28, 2542 DOI: 10.3390/molecules28062542 ABSTRACT: LsrK is a bacterial kinase that triggers the quorum sensing, and it represents a druggable target for the identification of new agents for fighting antimicrobial resistance. Herein,
• From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells
  Listro, R., Malacrida, A., Ambrosio, F.A., Rossino, G., Di Giacomo, M., Cavalloro, V., Garbagnoli, M., Linciano, P., Rossi, D., Cavaletti, G., Costa, G., Alcaro, S., Miloso, M., Collina, S. (2022) International Journal of Molecular Science, 23(21), 13061. DOI: 10.3390/ijms232113061 ABSTRACT: The insurgence of drug resistance in treating Multiple Myeloma (MM) still represents a major hamper in