Bioactive Compound Synthesis and Design

Identification of a novel extracellular inhibitor of FGF2/FGFR signaling axis by combined Virtual Screening and NMR Spectroscopy approach

13 April 2023 admin Publication

Pagano, K.; Listro, R.; Linciano, P.; Rossi, D.; Longhi, E.; Taraboletti, G.; Molinari, H.; Collina, S.; Ragona, L. (2023) Bioorganic Chemistry, 106529 DOI: 10.1016/j.bioorg.2023.106529 ABSTRACT: The aberrant activation

Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

13 April 2023 admin Publication

Alfano, A.I.; Pelliccia, S.; Rossino, G.; Chianese, O.; Summa, V.; Collina, S.; Brindisi, M. (2023) ACS Med. Chem. Lett.14(3), 326–337 DOI: 10.1021/acsmedchemlett.3c00010 ABSTRACT: The efficacy, safety, and scale-up of several chemical rearrangements

Photo-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds

13 April 2023 admin Publication

Alfano, A.I.; Pelliccia, S.; Rossino, G.; Chianese, O.; Summa, V.; Collina, S.; Brindisi M. (2023) ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.3c00072 In recent years, photochemistry has increasingly emerged

Structural Insights into the Ligand–LsrK Kinase Binding Mode: A Step Forward in the Discovery of Novel Antimicrobial Agents

13 March 2023 admin Publication

Listro, R.; Milli, G.; Pellegrini, A.; Motta, C.; Cavalloro, V.; Martino, E.; Kirchmair, J.; Pietrocola, G.; Rossi, D.; Linciano, P.; Collina, S. (2023) Molecules, 28, 2542

From Nature to Synthetic Compounds: Novel 1(N),2,3 Trisubstituted-5-oxopyrrolidines Targeting Multiple Myeloma Cells

27 October 2022 admin Publication

Listro, R., Malacrida, A., Ambrosio, F.A., Rossino, G., Di Giacomo, M., Cavalloro, V., Garbagnoli, M., Linciano, P., Rossi, D., Cavaletti, G., Costa, G., Alcaro, S.,

Biocatalysis: A Smart and Green Tool for the Preparation of Chiral Drugs

11 October 2022 admin Publication

Rossino, G., Robescu, M. S., Licastro, E., Tedesco, C., Martello, I., Maffei, L., Vincenti, G., Bavaro, T., Collina, S. (2022) Chirality, 34(11), pp. 1403–1418. DOI: 10.1002/chir.23498 ABSTRACT:

Synthesis and Characterization of a “Clickable” PBR28 TSPO-Selective Ligand Derivative Suitable for the Functionalization of Biodegradable Polymer Nanoparticles.

11 October 2022 admin Publication

Auriemma, R., Sponchioni, M., Capasso Palmiero, U., Rossino, G., Rossetti, A., Marsala, A., Collina, S., Sacchetti, A., Moscatelli, D., Peviani, M. (2021) Nanomaterials, 11, 1693. DOI: 10.3390/nano11071693

Effects of endocrine active contaminating pesticides on RACK1 expression and immunological consequences in THP-1 cells

11 October 2022 admin Publication

Maddalon, A., Masi, M., Iulini, M., Linciano, P., Galbiati, V., Marinovich, M., Racchi, M., Buoso, E., Corsini, E. (2022) Environmental Toxicology and Pharmacology, 95, art.

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1.

11 October 2022 admin Publication

Pöhner, I., Quotadamo, A., Panecka-Hofman, J., Luciani, R., Santucci, M., Linciano, P., Landi, G., Di Pisa, F., Dello Iacono, L., Pozzi, C., Mangani, S., Gul,