Publications

Rossino, G., Rui, M., Pozzetti, L., Schepmann, D., Wünsch, B., Zampieri, D., Pellavio, G., Laforenza, U., Rinaldi, S., Colombo, G., Morelli, L., Linciano, P., Rossi, D., Collina, S.
Setup and validation of a reliable docking protocol for the development of neuroprotective agents by targeting the sigma-1 receptor (S1R)
(2020) International Journal of Molecular Sciences, 21 (20), art. no. 7708, pp. 1-21.
DOI: 10.3390/ijms21207708

Gütschow, M., Eynde, J.J.V., Jampilek, J., Kang, C., Mangoni, A.A., Fossa, P., Karaman, R., Trabocchi, A., Scott, P.J.H., Reynisson, J., Rapposelli, S., Galdier, S., Winum, J.-Y., Brullo, C., Prokai-Tatrai, K., Sharma, A.K., Schapira, M., Azuma, Y.-T., Cerchia, L., Spete, M., Torri, G., Collina, S., Geronikaki, A., García-Sosa, A.T., Helena Vasconcelos, M., Sousa, M.E., Kosalec, I., Tuccinardi, T., Duarte, I.F., Salvador, J.A.R., Bertinaria, M., Pellecchia, M., Amato, J., Rastelli, G., Gomes, P.A.C., Guedes, R.C., Sabatier, J.-M., Estévez-Braun, A., Pagano, B., Mangani, S., Ragno, R., Kokotos, G., Brindisi, M., González, F.V., Borges, F., Miloso, M., Rautio, J., Muñoz-Torrero, D.
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-7
(2020) Molecules, 25 (13), art. no. 2968, .
DOI: 10.3390/molecules25132968

Listro, R., Stotani, S., Rossino, G., Rui, M., Malacrida, A., Cavaletti, G., Cortesi, M., Arienti, C., Tesei, A., Rossi, D., Giacomo, M.D., Miloso, M., Collina, S.
Exploring the RC-106 Chemical Space: Design and Synthesis of Novel (E)-1-(3-Arylbut-2-en-1-yl)-4-(Substituted) Piperazine Derivatives as Potential Anticancer Agents
(2020) Frontiers in Chemistry, 8, art. no. 495, .
DOI: 10.3389/fchem.2020.00495

Volpe, S.D., Listro, R., Parafioriti, M., Di Giacomo, M., Rossi, D., Ambrosio, F.A., Costa, G., Alcaro, S., Ortuso, F., Hirsch, A.K.H., Vasile, F., Collina, S.
BOPC1 Enantiomers Preparation and HuR Interaction Study. From Molecular Modeling to a Curious DEEP-STD NMR Application
(2020) ACS Medicinal Chemistry Letters, 11 (5), pp. 883-888.
DOI: 10.1021/acsmedchemlett.9b00659

Distante, F., Collina, S., Quadrelli, P.
A practical synthesis of (3-(phenanthren-9-yl)-4,5-dihydroisoxazol-5-yl)methyl (tert-butoxycarbonyl)-L-alaninate
(2020) Arkivoc, 2020 (6), .
DOI: 10.24820/ARK.5550190.P011.160dummy2

Rossino, G., Orellana, I., Caballero, J., Schepmann, D., Wünsch, B., Rui, M., Rossi, D., González-Avendaño, M., Collina, S., Vergara-Jaque, A.
New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative
(2020) Journal of Chemical Information and Modeling, 60 (2), pp. 756-765.
DOI: 10.1021/acs.jcim.9b00649

Cavalloro, V., Russo, K., Vasile, F., Pignataro, L., Torretta, A., Donini, S., Semrau, M.S., Storici, P., Rossi, D., Rapetti, F., Brullo, C., Parisini, E., Bruno, O., Collina, S.
Insight into GEBR-32a: Chiral resolution, absolute configuration and enantiopreference in PDE4D inhibition
(2020) Molecules, 25 (4), art. no. 935, .
DOI: 10.3390/molecules25040935

Senatore, R., Malik, M., Touqeer, S., Listro, R., Collina, S., Holzer, W., Pace, V.
Straightforward and direct access to β-seleno- amines and sulfonylamides via the controlled addition of phenylselenomethyllithium (LiCH2SePh) to imines
(2020) Tetrahedron, art. no. 131220, .
DOI: 10.1016/j.tet.2020.131220

Vigani, B., Rossi, S., Sandri, G., Bonferoni, M.C., Rui, M., Collina, S., Fagiani, F., Lanni, C., Ferrari, F.
Dual-functioning scaffolds for the treatment of spinal cord injury: Alginate nanofibers loaded with the sigma 1 receptor (S1R) Agonist RC-33 in chitosan films
(2020) Marine Drugs, 18 (1), art. no. 21, .
DOI: 10.3390/md18010021

Vanden Eynde, J.J., Mangoni, A.A., Rautio, J., Leprince, J., Azuma, Y.-T., García-Sosa, A.T., Hulme, C., Jampilek, J., Karaman, R., Li, W., Gomes, P.A.C., Hadjipavlou-Litina, D., Capasso, R., Geronikaki, A., Cerchia, L., Sabatier, J.-M., Ragno, R., Tuccinardi, T., Trabocchi, A., Winum, J.-Y., Luque, F.J., Prokai-Tatrai, K., Spetea, M., Gütschow, M., Kosalec, I., Guillou, C., Vasconcelos, M.H., Kokotos, G., Rastelli, G., De Sousa, M.E., Manera, C., Gemma, S., Mangani, S., Siciliano, C., Galdiero, S., Liu, H., Scott, P.J.H., De Los Ríos, C., Agrofoglio, L.A., Collina, S., Guedes, R.C., Muñoz-Torrero, D.
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6
(2020) Molecules, 25 (1), art. no. 119, .
DOI: 10.3390/molecules25010119

Zampieri, D., Fortuna, S., Calabretti, A., Romano, M., Menegazzi, R., Schepmann, D., Wünsch, B., Collina, S., Zanon, D., Mamolo, M.G.
Discovery of new potent dual sigma receptor/GluN2b ligands with antioxidant property as neuroprotective agents
(2019) European Journal of Medicinal Chemistry, 180, pp. 268-282.
DOI: 10.1016/j.ejmech.2019.07.012

Velázquez-Libera, J.L., Rossino, G., Navarro-Retamal, C., Collina, S., Caballero, J.
Docking, Interaction Fingerprint, and Three-Dimensional Quantitative Structure–Activity Relationship (3D-QSAR) of Sigma1 Receptor Ligands, Analogs of the Neuroprotective Agent RC-33
(2019) Frontiers in Chemistry, 7, art. no. 496, .
DOI: 10.3389/fchem.2019.00496

Martino, E., Della Volpe, S., Cavalloro, V., Amri, B., Kaab, L.B.B., Marrubini, G., Rossi, D., Collina, S.
The use of a microwave-assisted solvent extraction coupled with HPLC-UV/PAD to assess the quality of Marrubium vulgare L. (white horehound) herbal raw material
(2019) Phytochemical Analysis, 30 (4), pp. 377-384.
DOI: 10.1002/pca.2820

Moiola, M., Crespi, S., Memeo, M., Collina, S., Overkleeft, H., Florea, B., Quadrelli, P.
Scope and Limitations of Boron Fluorescent Complexes from Stable Nitrile Oxides in ABPP Assays
(2019) ACS Omega, 4 (4), pp. 7766-7774.
DOI: 10.1021/acsomega.9b00672

Della Volpe, S., Nasti, R., Queirolo, M., Unver, M.Y., Jumde, V.K., Dömling, A., Vasile, F., Potenza, D., Ambrosio, F.A., Costa, G., Alcaro, S., Zucal, C., Provenzani, A., Di Giacomo, M., Rossi, D., Hirsch, A.K.H., Collina, S.
Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies
(2019) ACS Medicinal Chemistry Letters, 10 (4), pp. 615-620.
DOI: 10.1021/acsmedchemlett.8b00600

Vigani, B., Rossi, S., Gentile, M., Sandri, G., Bonferoni, M.C., Cavalloro, V., Martino, E., Collina, S., Ferrari, F.
Development of a mucoadhesive and an in situ gelling formulation based on κ-carrageenan for application on oral mucosa and esophagus walls. II. Loading of a bioactive hydroalcoholic extract
(2019) Marine Drugs, 17 (3), art. no. 153, .
DOI: 10.3390/md17030153

Raimondi, M.V., Listro, R., Cusimano, M.G., La Franca, M., Faddetta, T., Gallo, G., Schillaci, D., Collina, S., Leonchiks, A., Barone, G.
Pyrrolomycins as antimicrobial agents. Microwave-assisted organic synthesis and insights into their antimicrobial mechanism of action
(2019) Bioorganic and Medicinal Chemistry, 27 (5), pp. 721-728.
DOI: 10.1016/j.bmc.2019.01.010

Rui, M., Rossino, G., Rossi, D., Collina, S.
CHAPTER 12: Sigma Receptors as New Target for Multiple Sclerosis
(2019) RSC Drug Discovery Series, 2019-January (70), pp. 264-284.
DOI: 10.1039/9781788016070-00264

Raimondi, M.V., Randazzo, O., Franca, M.L., Barone, G., Vignoni, E., Rossi, D., Collina, S.
DHFR inhibitors: Reading the past for discovering novel anticancer agents
(2019) Molecules, 24 (6), art. no. 1140, .
DOI: 10.3390/molecules24061140

Martino, E., Tarantino, M., Bergamini, M., Castelluccio, V., Coricello, A., Falcicchio, M., Lorusso, E., Collina, S.
Artemisinin and its derivatives; Ancient tradition inspiring the latest therapeutic approaches against malaria
(2019) Future Medicinal Chemistry, 11 (12), pp. 1443-1459.
DOI: 10.4155/fmc-2018-0337

Stotani, S., Gatta, V., Medarametla, P., Padmanaban, M., Karawajczyk, A., Giordanetto, F., Tammela, P., Laitinen, T., Poso, A., Tzalis, D., Collina, S.
DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity to Fight Antimicrobial Resistance
(2019) Journal of Medicinal Chemistry, .
DOI: 10.1021/acs.jmedchem.9b00025

Malacrida, A., Cavalloro, V., Martino, E., Cassetti, A., Nicolini, G., Rigolio, R., Cavaletti, G., Mannucci, B., Vasile, F., Di Giacomo, M., Collina, S., Miloso, M.
Anti-multiple myeloma potential of secondary metabolites from hibiscus sabdariffa
(2019) Molecules, 24 (13), art. no. 2500, .
DOI: 10.3390/molecules24132500

Tesei, A., Cortesi, M., Pignatta, S., Arienti, C., Massimo Dondio, G., Bigogno, C., Malacrida, A., Miloso, M., Meregalli, C., Chiorazzi, A., Carozzi, V., Cavaletti, G., Rui, M., Marra, A., Rossi, D., Collina, S.
Anti-tumor efficacy assessment of the sigma receptor pan modulator RC-106. A promising therapeutic tool for pancreatic cancer
(2019) Frontiers in Pharmacology, 10 (MAY), art. no. 490, .
DOI: 10.3389/fphar.2019.00490

Mangoni, A.A., Guillou, C., Eynde, J.J.V., Hulme, C., Jampilek, J., Li, W., Prokai-Tatrai, K., Rautio, J., Collina, S., Tuccinardi, T., Sousa, M.E., Sabatier, J.-M., Galdiero, S., Karaman, R., Kokotos, G., Torri, G., Javier Luque, F., Helena Vasconcelos, M., Hadjipavlou-Litina, D., Siciliano, C., Gütschow, M., Ragno, R., Gomes, P.A.C., Agrofoglio, L.A., Muñoz-Torrero, D.
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-4
(2019) Molecules, 24 (1), pp. 1-12.
DOI: 10.3390/molecules24010130

Mangoni, A.A., Eynde, J.J.V., Jampilek, J., Hadjipavlou-Litina, D., Liu, H., Reynisson, J., Sousa, M.E., Gomes, P.A.C., Prokai-Tatrai, K., Tuccinardi, T., Sabatier, J.-M., Luque, F.J., Rautio, J., Karaman, R., Vasconcelos, M.H., Gemma, S., Galdiero, S., Hulme, C., Collina, S., Gütschow, M., Kokotos, G., Siciliano, C., Capasso, R., Agrofoglio, L.A., Ragno, R., Muñoz-Torrero, D.
Breakthroughs in medicinal chemistry: New targets and mechanisms, New Drugs, New Hopes-5
(2019) Molecules, 24 (13), art. no. 2415, .
DOI: 10.3390/molecules24132415

Vasile, F., Della Volpe, S., Ambrosio, F.A., Costa, G., Unver, M.Y., Zucal, C., Rossi, D., Martino, E., Provenzani, A., Hirsch, A.K.H., Alcaro, S., Potenza, D., Collina, S.
Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach
(2018) Scientific Reports, 8 (1), art. no. 13780, .
DOI: 10.1038/s41598-018-32084-z

Stotani, S., Gatta, V., Medda, F., Padmanaban, M., Karawajczyk, A., Tammela, P., Giordanetto, F., Tzalis, D., Collina, S.
A versatile strategy for the synthesis of 4,5-dihydroxy-2,3-pentanedione (DPD) and related compounds as potential modulators of bacterial quorum sensing
(2018) Molecules, 23 (10), art. no. 2545, .
DOI: 10.3390/molecules23102545

Rui, M., Rossino, G., Coniglio, S., Monteleone, S., Scuteri, A., Malacrida, A., Rossi, D., Catenacci, L., Sorrenti, M., Paolillo, M., Curti, D., Venturini, L., Schepmann, D., Wünsch, B., Liedl, K.R., Cavaletti, G., Pace, V., Urban, E., Collina, S.
Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents
(2018) European Journal of Medicinal Chemistry, 158, pp. 353-370.
DOI: 10.1016/j.ejmech.2018.09.010

Martino, E., Casamassima, G., Castiglione, S., Cellupica, E., Pantalone, S., Papagni, F., Rui, M., Siciliano, A.M., Collina, S.
Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead
(2018) Bioorganic and Medicinal Chemistry Letters, 28 (17), pp. 2816-2826.
DOI: 10.1016/j.bmcl.2018.06.044

Tesei, A., Cortesi, M., Zamagni, A., Arienti, C., Pignatta, S., Zanoni, M., Paolillo, M., Curti, D., Rui, M., Rossi, D., Collina, S.
Sigma receptors as endoplasmic reticulum stress “gatekeepers” and their modulators as emerging new weapons in the fight against cancer
(2018) Frontiers in Pharmacology, 9 (JUN), art. no. 711, .
DOI: 10.3389/fphar.2018.00711

Rivara, S., Scalvini, L., Lodola, A., Mor, M., Caignard, D.-H., Delagrange, P., Collina, S., Lucini, V., Scaglione, F., Furiassi, L., Mari, M., Lucarini, S., Bedini, A., Spadoni, G.
Tetrahydroquinoline Ring as a Versatile Bioisostere of Tetralin for Melatonin Receptor Ligands
(2018) Journal of Medicinal Chemistry, 61 (8), pp. 3726-3737.
DOI: 10.1021/acs.jmedchem.8b00359

Rossino, G., Raimondi, M.V., Rui, M., Di Giacomo, M., Rossi, D., Collina, S.
PEG 400/cerium ammonium nitrate combined with microwave-assisted synthesis for rapid access to beta-amino ketones. an easy-to-use protocol for discovering new hit compounds
(2018) Molecules, 23 (4), art. no. 775, .
DOI: 10.3390/molecules23040775

Cosimelli, B., Greco, G., Laneri, S., Novellino, E., Sacchi, A., Collina, S., Rossi, D., Cosconati, S., Barresi, E., Taliani, S., Trincavelli, M.L., Martini, C.
Studies on enantioselectivity of chiral 4-acetylamino-6-alkyloxy-2-alkylthiopyrimidines acting as antagonists of the human A3 adenosine receptor
(2018) MedChemComm, 9 (1), pp. 81-86.
DOI: 10.1039/c7md00375g

Muñoz-Torrero, D., Mangoni, A.A., Liu, H., Hulme, C., Rautio, J., Karaman, R., De Sousa, M.E., Prokai-Tatrai, K., Sabatier, J.-M., Siciliano, C., Luque, F.J., Kokotos, G., Ragno, R., Collina, S., Guillou, C., Tschow, M.G., Agrofoglio, L.A.
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes–2
(2018) Molecules, 23 (1), art. no. 65, .
DOI: 10.3390/molecules23010065

Mangoni, A.A., Tuccinardi, T., Collina, S., Vanden Eynde, J.J., Mu oz-Torrero, D., Karaman, R., Siciliano, C., Emília de Sousa, M., Prokai-Tatrai, K., Rautio, J., Guillou, C., G tschow, M., Galdiero, S., Liu, H., Agrofoglio, L.A., Sabatier, J.-M., Hulme, C., Kokotos, G., You, Q., Gomes, P.A.C.
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-3
(2018) Molecules, 23 (7), art. no. 1596, .
DOI: 10.3390/molecules23071596

Pellavio, G., Rui, M., Caliogna, L., Martino, E., Gastaldi, G., Collina, S., Laforenza, U.
Regulation of aquaporin functional properties mediated by the antioxidant effects of natural compounds
(2017) International Journal of Molecular Sciences, 18 (12), art. no. 2665, .
DOI: 10.3390/ijms18122665

Rossi, D., Tarantino, M., Rossino, G., Rui, M., Juza, M., Collina, S.
Approaches for multi-gram scale isolation of enantiomers for drug discovery
(2017) Expert Opinion on Drug Discovery, 12 (12), pp. 1253-1269.
DOI: 10.1080/17460441.2017.1383981

Collina, S., Rui, M., Stotani, S., Bignardi, E., Rossi, D., Curti, D., Giordanetto, F., Malacrida, A., Scuteri, A., Cavaletti, G.
Are sigma receptor modulators a weapon against multiple sclerosis disease?
(2017) Future Medicinal Chemistry, 9 (17), pp. 2029-2051.
DOI: 10.4155/fmc-2017-0122

Amri, B., Martino, E., Vitulo, F., Corana, F., Ben-Kaâb, L.B., Rui, M., Rossi, D., Mori, M., Rossi, S., Collina, S.
Marrubium vulgare l. leave extract: Phytochemical composition, antioxidant and wound healing properties
(2017) Molecules, 22 (11), art. no. 1851, .
DOI: 10.3390/molecules22111851

Nasti, R., Rossi, D., Amadio, M., Pascale, A., Unver, M.Y., Hirsch, A.K.H., Collina, S.
Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs
(2017) Journal of Medicinal Chemistry, 60 (20), pp. 8257-8267.
DOI: 10.1021/acs.jmedchem.6b01871

Rossi, D., Nasti, R., Collina, S., Mazzeo, G., Ghidinelli, S., Longhi, G., Memo, M., Abbate, S.
The role of chirality in a set of key intermediates of pharmaceutical interest, 3-aryl-substituted-γ-butyrolactones, evidenced by chiral HPLC separation and by chiroptical spectroscopies
(2017) Journal of Pharmaceutical and Biomedical Analysis, 144, pp. 41-51.
DOI: 10.1016/j.jpba.2017.01.007

Amri, B., Kaab, S.B., Gouia, H., Martino, E., Collina, S., Kaâb, L.B.B.
Copper-induced changes in nutrient uptake, enzymatic and non-enzymatic antioxidant systems in horehound (Marrubium vulgare L.)
(2017) Botanical Sciences, 95 (3), pp. 565-575.
DOI: 10.17129/botsci.778

Rui, M., Nasti, R., Bignardi, E., Volpe, S.D., Rossino, G., Rossi, D., Collina, S.
PKC in regenerative therapy: New insights for old targets
(2017) Pharmaceuticals, 10 (2), art. no. 46, .
DOI: 10.3390/ph10020046

Pace, V., Castoldi, L., Monticelli, S., Rui, M., Collina, S.
New Perspectives in Lithium Carbenoid Mediated Homologations
(2017) Synlett, 28 (8), art. no. st-2016-p0838-sp, pp. 879-888.
DOI: 10.1055/s-0036-1588139

Collina, S., Bignardi, E., Rui, M., Rossi, D., Gaggeri, R., Zamagni, A., Cortesi, M., Tesei, A.
Are sigma modulators an effective opportunity for cancer treatment? A patent overview (1996-2016)
(2017) Expert Opinion on Therapeutic Patents, 27 (5), pp. 565-578.
DOI: 10.1080/13543776.2017.1276569

Muñoz-Torrero, D., Mangoni, A.A., Guillou, C., Collina, S., Eynde, J.J.V., Rautio, J., Keseru, G.M., Hulme, C., Chibale, K., Luque, F.J., Karaman, R., Gütschow, M., Liu, H., Ragno, R.
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes
(2017) Molecules, 22 (5), art. no. 743, .
DOI: 10.3390/molecules22050743

Rossi, D., Ahmed, K.M., Gaggeri, R., Volpe, S.D., Maggi, L., Mazzeo, G., Longhi, G., Abbate, S., Corana, F., Martino, E., Machado, M., Varandas, R., Do Céu Sousa, M., Collina, S.
(R)-(-)-Aloesaponol III 8-methyl ether from eremurus persicus: A novel compound against leishmaniosis
(2017) Molecules, 22 (4), art. no. 519, .
DOI: 10.3390/molecules22040519

Curti, V., Di Lorenzo, A., Rossi, D., Martino, E., Capelli, E., Collina, S., Daglia, M.
Enantioselective modulatory effects of naringenin enantiomers on the expression levels of miR-17-3p involved in endogenous antioxidant defenses
(2017) Nutrients, 9 (3), art. no. 215, .
DOI: 10.3390/nu9030215

Dichiara, M., Marrazzo, A., Prezzavento, O., Collina, S., Rescifina, A., Amata, E.
Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases
(2017) ChemMedChem, 12 (16), pp. 1235-1253.
DOI: 10.1002/cmdc.201700259

Martino, E., Della Volpe, S., Terribile, E., Benetti, E., Sakaj, M., Centamore, A., Sala, A., Collina, S.
The long story of camptothecin: From traditional medicine to drugs
(2017) Bioorganic and Medicinal Chemistry Letters, 27 (4), pp. 701-707.
DOI: 10.1016/j.bmcl.2016.12.085

Rossi, D., Rui, M., Di Giacomo, M., Schepmann, D., Wünsch, B., Monteleone, S., Liedl, K.R., Collina, S.
Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines
(2017) Bioorganic and Medicinal Chemistry, 25 (1), pp. 11-19.
DOI: 10.1016/j.bmc.2016.10.005

Rui, M., Marra, A., Pace, V., Juza, M., Rossi, D., Collina, S.
Novel enantiopure sigma receptor modulators: Quick (semi-)preparative chiral resolution via hplc and absolute configuration assignment
(2016) Molecules, 21 (9), art. no. 1210, .
DOI: 10.3390/molecules21091210

Shah, M.R., Ishtiaq, Hizbullah, S.M., Habtemariam, S., Zarrelli, A., Muhammad, A., Collina, S., Khan, I.
Protein tyrosine phosphatase 1B inhibitors isolated from Artemisia roxburghiana
(2016) Journal of Enzyme Inhibition and Medicinal Chemistry, 31 (4), pp. 563-567.
DOI: 10.3109/14756366.2015.1047358

Marra, A., Rossi, D., Maggi, L., Corana, F., Mannucci, B., Peviani, M., Curti, D., Collina, S.
Development of easy-to-use reverse-phase liquid chromatographic methods for determining PRE-084, RC-33 and RC-34 in biological matrices. The first step for in vivo analysis of sigma1 receptor agonists
(2016) Biomedical Chromatography, 30 (4), pp. 645-651.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959529516&doi=10.1002%2fbmc.3609&partnerID=40&md5=ea00d8486c8fee38576d07d8849fdba1

DOI: 10.1002/bmc.3609

Marra, A., Rossi, D., Pignataro, L., Bigogno, C., Canta, A., Oggioni, N., Malacrida, A., Corbo, M., Cavaletti, G., Peviani, M., Curti, D., Dondio, G., Collina, S.
Toward the identification of neuroprotective agents: G-scale synthesis, pharmacokinetic evaluation and CNS distribution of (R)-RC-33, a promising SIGMA1 receptor agonist
(2016) Future Medicinal Chemistry, 8 (3), pp. 287-295.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960092888&doi=10.4155%2ffmc.15.191&partnerID=40&md5=a8115daed647b3b6ae7b6285ce514fb9

DOI: 10.4155/fmc.15.191

Rossi, D., Marra, A., Rui, M., Brambilla, S., Juza, M., Collina, S.
“Fit-for-purpose” development of analytical and (semi)preparative enantioselective high performance liquid and supercritical fluid chromatography for the access to a novel σ1 receptor agonist
(2016) Journal of Pharmaceutical and Biomedical Analysis, 118, pp. 363-369.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84959386497&doi=10.1016%2fj.jpba.2015.10.047&partnerID=40&md5=9bf30c5df759a710e11587f0d6e93830

DOI: 10.1016/j.jpba.2015.10.047

Rossi, D., Nasti, R., Marra, A., Meneghini, S., Mazzeo, G., Longhi, G., Memo, M., Cosimelli, B., Greco, G., Novellino, E., Da Settimo, F., Martini, C., Taliani, S., Abbate, S., Collina, S.
Enantiomeric 4-Acylamino-6-alkyloxy-2 Alkylthiopyrimidines As Potential A3Adenosine Receptor Antagonists: HPLC Chiral Resolution and Absolute Configuration Assignment by a Full Set of Chiroptical Spectroscopy
(2016) Chirality, 28 (5), pp. 434-440.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963978807&doi=10.1002%2fchir.22599&partnerID=40&md5=1ecb06a5ecb88e2c2f84ae78fb0d5ad6

DOI: 10.1002/chir.22599

Rui, M., Rossi, D., Marra, A., Paolillo, M., Schinelli, S., Curti, D., Tesei, A., Cortesi, M., Zamagni, A., Laurini, E., Pricl, S., Schepmann, D., Wűnsch, B., Urban, E., Pace, V., Collina, S.
Synthesis and biological evaluation of new aryl-alkyl(alkenyl)-4-benzylpiperidines, novel Sigma Receptor (SR) modulators, as potential anticancer-agents
(2016) European Journal of Medicinal Chemistry, 124, pp. 649-665.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84987974420&doi=10.1016%2fj.ejmech.2016.08.067&partnerID=40&md5=9b8eb67abfaf5fc0eb3659ea81d11d05

DOI: 10.1016/j.ejmech.2016.08.067

Rossi, D., Talman, V., Gennäs, G.B.A., Marra, A., Picconi, P., Nasti, R., Serra, M., Ann, J., Amadio, M., Pascale, A., Tuominen, R.K., Yli-Kauhaluoma, J., Lee, J., Collina, S.
Beyond the affinity for protein kinase C: Exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands
(2015) MedChemComm, 6 (4), pp. 547-554.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84928007328&doi=10.1039%2fc4md00564c&partnerID=40&md5=d3134eb625e54bfb86955d2306af9e4d

DOI: 10.1039/c4md00564c

Quesada-Romero, L., Mena-Ulecia, K., Zuñiga, M., De-la-Torre, P., Rossi, D., Tiznado, W., Collina, S., Caballero, J.
Optimal graph-based and simplified molecular input line entry system-based descriptors for quantitative structure-activity relationship analysis of arylalkylaminoalcohols, arylalkenylamines, and arylalkylamines as σ1 receptor ligands
(2015) Journal of Chemometrics, 29 (1), pp. 13-20.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921434801&doi=10.1002%2fcem.2650&partnerID=40&md5=89a111571baabf4a53ea5b882be0d2d4

DOI: 10.1002/cem.2650

Rossi, D., Marra, A., Rui, M., Laurini, E., Fermeglia, M., Pricl, S., Schepmann, D., Wuensch, B., Peviani, M., Curti, D., Collina, S.
A step forward in the sigma enigma: A role for chirality in the sigma1 receptor-ligand interaction?
(2015) MedChemComm, 6 (1), pp. 138-146.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84920384304&doi=10.1039%2fc4md00349g&partnerID=40&md5=a779707a57935fe4cc698c2aa5d1dbdb

DOI: 10.1039/c4md00349g

Vasile, F., Rossi, D., Collina, S., Potenza, D.
Diffusion-ordered spectroscopy and saturation transfer difference NMR spectroscopy studies of selective interactions between ELAV protein fragments and an mRNA target
(2014) European Journal of Organic Chemistry, 2014 (29), pp. 6399-6404.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954198166&doi=10.1002%2fejoc.201403014&partnerID=40&md5=b8ea0bcd3259f367ba1c5777c657a606

DOI: 10.1002/ejoc.201403014

Chlapanidas, T., Perteghella, S., Leoni, F., Faragò, S., Marazzi, M., Rossi, D., Martino, E., Gaggeri, R., Collina, S.
TNF-α blocker effect of naringenin-loaded sericin microparticles that are potentially useful in the treatment of psoriasis
(2014) International Journal of Molecular Sciences, 15 (8), pp. 13624-13636.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925243024&doi=10.3390%2fijms150813624&partnerID=40&md5=0805ed67ed0e06eb992ec1369b950536

DOI: 10.3390/ijms150813624

Cateni, F., Zilic, J., Altieri, T., Zacchigna, M., Procida, G., Gaggeri, R., Rossi, D., Collina, S.
Lipid metabolites with free-radical scavenging activity from Euphorbia helioscopia L.
(2014) Chemistry and Physics of Lipids, 181, pp. 90-98.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901628200&doi=10.1016%2fj.chemphyslip.2014.03.001&partnerID=40&md5=b4100bd23d0a48fda6525f4c79147a19

DOI: 10.1016/j.chemphyslip.2014.03.001

Peviani, M., Salvaneschi, E., Bontempi, L., Petese, A., Manzo, A., Rossi, D., Salmona, M., Collina, S., Bigini, P., Curti, D.
Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation
(2014) Neurobiology of Disease, 62, pp. 218-232.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886816838&doi=10.1016%2fj.nbd.2013.10.010&partnerID=40&md5=b4e6275a44b006950390666843684fbc

DOI: 10.1016/j.nbd.2013.10.010

Lucconi, G., Chlapanidas, T., Martino, E., Gaggeri, R., Perteghella, S., Rossi, D., Faragò, S., Vigo, D., Faustini, M., Collina, S., Torre, M.L.
Formulation of microspheres containing Crataegus monogyna Jacq. extract with free radical scavenging activity
(2014) Pharmaceutical Development and Technology, 19 (1), pp. 65-72.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899993963&doi=10.3109%2f10837450.2012.752387&partnerID=40&md5=b2027b12d2c5dd16303bdb2a3e58071a

DOI: 10.3109/10837450.2012.752387

Rossi, D., Pedrali, A., Marra, A., Pignataro, L., Schepmann, D., Wünsch, B., Ye, L., Leuner, K., Peviani, M., Curti, D., Azzolina, O., Collina, S.
Studies on the Enantiomers of RC-33 as Neuroprotective Agents: Isolation, Configurational Assignment, and Preliminary Biological Profile
(2013) Chirality, 25 (11), pp. 814-822.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886639929&doi=10.1002%2fchir.22223&partnerID=40&md5=d7afd122c130e1dc226877dc4e4f9387

DOI: 10.1002/chir.22223

Rossi, D., Pedrali, A., Gaggeri, R., Marra, A., Pignataro, L., Laurini, E., DalCol, V., Fermeglia, M., Pricl, S., Schepmann, D., Wünsch, B., Peviani, M., Curti, D., Collina, S.
Chemical, pharmacological, and in vitro metabolic stability studies on enantiomerically pure RC-33 compounds: Promising neuroprotective agents acting as σ1 receptor agonists
(2013) ChemMedChem, 8 (9), pp. 1514-1527.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84883051500&doi=10.1002%2fcmdc.201300218&partnerID=40&md5=fe7f67e0a36c691bc800f855504076ea

DOI: 10.1002/cmdc.201300218

Gaggeri, R., Rossi, D., Daglia, M., Leoni, F., Avanzini, M.A., Mantelli, M., Juza, M., Collina, S.
An eco-friendly enantioselective access to (R)-naringenin as inhibitor of proinflammatory cytokine release
(2013) Chemistry and Biodiversity, 10 (8), pp. 1531-1538.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84882387074&doi=10.1002%2fcbdv.201200227&partnerID=40&md5=724a79d8ada029aa483506f5ba78761d

DOI: 10.1002/cbdv.201200227

Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije Af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R.K., Pascale, A.
The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells
(2013) Pharmacological Research, 73, pp. 44-54.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878389915&doi=10.1016%2fj.phrs.2013.04.008&partnerID=40&md5=ce509ecf1de21160cc1819731db61e3d

DOI: 10.1016/j.phrs.2013.04.008

Amadio, M., Pascale, A., Govoni, S., Laurini, E., Pricl, S., Gaggeri, R., Rossi, D., Collina, S.
Identification of peptides with ELAV-like mRNA-stabilizing effect: An integrated in vitro/in silico approach
(2013) Chemical Biology and Drug Design, 81 (6), pp. 707-714.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84878345245&doi=10.1111%2fcbdd.12117&partnerID=40&md5=317d9bc9833255ba7c1c04074826cfb2

DOI: 10.1111/cbdd.12117

Collina, S., Gaggeri, R., Marra, A., Bassi, A., Negrinotti, S., Negri, F., Rossi, D.
Sigma receptor modulators: A patent review
(2013) Expert Opinion on Therapeutic Patents, 23 (5), pp. 597-613.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876567515&doi=10.1517%2f13543776.2013.769522&partnerID=40&md5=ff9b94d865e6d3a16e5f3472e10afd9f

DOI: 10.1517/13543776.2013.769522

Rossi, D., Marra, A., Picconi, P., Serra, M., Catenacci, L., Sorrenti, M., Laurini, E., Fermeglia, M., Pricl, S., Brambilla, S., Almirante, N., Peviani, M., Curti, D., Collina, S.
Identification of RC-33 as a potent and selective σ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells. Part 2: G-Scale synthesis, physicochemical characterization and in vitro metabolic stability
(2013) Bioorganic and Medicinal Chemistry, 21 (9), pp. 2577-2586.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84876131740&doi=10.1016%2fj.bmc.2013.02.029&partnerID=40&md5=8e5a7c1e0a2997095b17f279e3fcf2b7

DOI: 10.1016/j.bmc.2013.02.029

Daglia, M., Ferrari, D., Collina, S., Curti, V.
Influence of in vitro simulated gastroduodenal digestion on methylglyoxal concentration of manuka (Lectospermum scoparium) honey
(2013) Journal of Agricultural and Food Chemistry, 61 (9), pp. 2140-2145.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84874917284&doi=10.1021%2fjf304299d&partnerID=40&md5=0aef4ffcd20774dd02d9fbb1d5ac8f99

DOI: 10.1021/jf304299d

Uddin, G., Rauf, A., Al-Othman, A.M., Collina, S., Arfan, M., Ali, G., Khan, I.
Pistagremic acid, a glucosidase inhibitor from Pistacia integerrima
(2012) Fitoterapia, 83 (8), pp. 1648-1652.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84870789737&doi=10.1016%2fj.fitote.2012.09.017&partnerID=40&md5=136f5311d7f9cff0eebb9f0739ceef31

DOI: 10.1016/j.fitote.2012.09.017

Caballero, J., Zilocchi, S., Tiznado, W., Collina, S.
Docking and quantitative structure-activity relationship studies for imidazo[1,2-a]pyrazines as inhibitors of checkpoint kinase-1
(2012) Medicinal Chemistry Research, 21 (8), pp. 1912-1920.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84866092851&doi=10.1007%2fs00044-011-9714-1&partnerID=40&md5=a5398c8ab0cc004ecef6eb123c9cf65f

DOI: 10.1007/s00044-011-9714-1

Caballero, J., Zilocchi, S., Tiznado, W., Rossi, D., Collina, S.
Models of the pharmacophoric pattern and affinity trend of methyl 2-(aminomethyl)-1-phenylcyclopropane-1-carboxylate derivatives as σ 1 ligands
(2012) Molecular Simulation, 38 (3), pp. 227-235.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84855946245&doi=10.1080%2f08927022.2011.614243&partnerID=40&md5=014340277c37e44d72c92efc33a88a2a

DOI: 10.1080/08927022.2011.614243

Gaggeri, R., Rossi, D., Christodoulou, M.S., Passarella, D., Leoni, F., Azzolina, O., Collina, S.
Chiral flavanones from Amygdalus lycioides spach: Structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation
(2012) Molecules, 17 (2), pp. 1665-1674.
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DOI: 10.3390/molecules17021665

Rossi, D., Pedrali, A., Urbano, M., Gaggeri, R., Serra, M., Fernández, L., Fernández, M., Caballero, J., Ronsisvalle, S., Prezzavento, O., Schepmann, D., Wuensch, B., Peviani, M., Curti, D., Azzolina, O., Collina, S.
Identification of a potent and selective ρ1 receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells
(2011) Bioorganic and Medicinal Chemistry, 19 (21), pp. 6210-6224.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-80054893631&doi=10.1016%2fj.bmc.2011.09.016&partnerID=40&md5=0b7034ee1f3ad81b1815445b51409f11

DOI: 10.1016/j.bmc.2011.09.016

Caballero, J., Zilocchi, S., Tiznado, W., Collina, S., Rossi, D.
Binding Studies and Quantitative Structure-Activity Relationship of 3-Amino-1H-Indazoles as Inhibitors of GSK3β
(2011) Chemical Biology and Drug Design, 78 (4), pp. 631-641.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-80052614834&doi=10.1111%2fj.1747-0285.2011.01186.x&partnerID=40&md5=7b67b51389c1753b5179d4e0927eb1c4

DOI: 10.1111/j.1747-0285.2011.01186.x

Gaggeri, R., Rossi, D., Collina, S., Mannucci, B., Baierl, M., Juza, M.
Quick development of an analytical enantioselective high performance liquid chromatography separation and preparative scale-up for the flavonoid naringenin
(2011) Journal of Chromatography A, 1218 (32), pp. 5414-5422.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-79960368560&doi=10.1016%2fj.chroma.2011.02.038&partnerID=40&md5=b8189725391b7d2a9907a0c466c6ff2d

DOI: 10.1016/j.chroma.2011.02.038

Rossi, D., Baraglia, A.C., Serra, M., Azzolina, O., Collina, S.
An efficient procedure based on a MW-assisted Horner-Wadsworth-Emmons reaction for the synthesis of (Z)-3,3-trisubstituted-α,β-unsaturated esters
(2010) Molecules, 15 (9), pp. 5928-5942.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-77957317113&doi=10.3390%2fmolecules15095928&partnerID=40&md5=999c844dc12ca5f028b9d515f9e7c955

DOI: 10.3390/molecules15095928

Rossi, D., Urbano, M., Pedrali, A., Serra, M., Zampieri, D., Mamolo, M.G., Laggner, C., Zanette, C., Florio, C., Schepmann, D., Wuensch, B., Azzolina, O., Collina, S.
Design, synthesis and SAR analysis of novel selective σ1 ligands (Part 2)
(2010) Bioorganic and Medicinal Chemistry, 18 (3), pp. 1204-1212.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-75149126120&doi=10.1016%2fj.bmc.2009.12.039&partnerID=40&md5=1c22fc98f73abfe438d5f05d2247bbeb

DOI: 10.1016/j.bmc.2009.12.039

Rossi, D., Amadio, M., Baraglia, A.C., Azzolina, O., Ratti, A., Govoni, S., Pascale, A., Collina, S.
Discovery of small peptides derived from embryonic lethal abnormal vision proteins structure showing RNA-stabilizing properties
(2009) Journal of Medicinal Chemistry, 52 (16), pp. 5017-5019.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-69049088805&doi=10.1021%2fjm900741e&partnerID=40&md5=8e7560e5967480a28fc84e3c935acf03

DOI: 10.1021/jm900741e

Comini, M., Pozzoli, C., Incerti, M., Rossi, D., Collina, S., Azzolina, O., di Vittorio, E., Morini, G., Poli, E.
Stereospecific effects of benzo[d]isothiazolyloxypropanolamine derivatives at β-adrenoceptors: Synthesis, chiral resolution, and biological activity in vitro
(2009) Chirality, 21 (2), pp. 284-291.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-60549095684&doi=10.1002%2fchir.20574&partnerID=40&md5=ffccf81c63ab91761af991bfd0deaa93

DOI: 10.1002/chir.20574

Rossi, D., Urbano, M., Baraglia, A.C., Serra, M., Bergamelli, F., Iannelli, M., Azzolina, O., Collina, S.
Polymer-assisted solution-phase synthesis under combined ultrasound and microwave irradiation: Preparation of α,β-unsaturated esters and carboxylic acids, key intermediates of novel sigma ligands
(2009) Synthetic Communications, 39 (18), pp. 3254-3262.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-68949158949&doi=10.1080%2f00397910902738112&partnerID=40&md5=211158a355e107c1a3da6473ebcc51e5

DOI: 10.1080/00397910902738112

Zampieri, D., Grazia Mamolo, M., Laurini, E., Zanette, C., Florio, C., Collina, S., Rossi, D., Azzolina, O., Vio, L.
Substituted benzo[d]oxazol-2(3H)-one derivatives with preference for the σ1 binding site
(2009) European Journal of Medicinal Chemistry, 44 (1), pp. 124-130.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-57949107456&doi=10.1016%2fj.ejmech.2008.03.011&partnerID=40&md5=2af6cfd7182d77e7e09c2e59c37e98fb

DOI: 10.1016/j.ejmech.2008.03.011

Martino, E., Collina, S., Rossi, D., Bazzoni, D., Gaggeri, R., Bracco, F., Azzolina, O.
Influence of the extraction mode on the yield of hyperoside, vitexin and vitexin-2-O-rhamnoside from Crataegus monogyna Jacq. (Hawthorn)
(2008) Phytochemical Analysis, 19 (6), pp. 534-540.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-57849118885&doi=10.1002%2fpca.1081&partnerID=40&md5=9e027993ae4d2e25e3d9ea3a6ea2c836

DOI: 10.1002/pca.1081

Mamolo, M.G., Zampieri, D., Zanette, C., Florio, C., Collina, S., Urbano, M., Azzolina, O., Vio, L.
Substituted benzylaminoalkylindoles with preference for the σ2 binding site
(2008) European Journal of Medicinal Chemistry, 43 (10), pp. 2073-2081.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-53149142527&doi=10.1016%2fj.ejmech.2007.09.012&partnerID=40&md5=775cdb6f5c879384b5cd4bf99d9c7f75

DOI: 10.1016/j.ejmech.2007.09.012

Urbano, M., Collina, S., Rossi, D., Carnevale Baraglia, A., Alcaro, S., Artese, A., Azzolina, O.
Design and synthesis of a (N-alkylaminoalkyl-substituted)arylalkenylamide drug discovery library
(2007) Letters in Drug Design and Discovery, 4 (8), pp. 605-610.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-37049020957&doi=10.2174%2f157018007782794581&partnerID=40&md5=948d7063c5e289a75031e5c1005016e4

DOI: 10.2174/157018007782794581

Collina, S., Rossi, D., Urbano, M., Carnevale Baraglia, A., Azzolina, O.
Microwave and polymer assisted synthesis of a small library of α,β-unsaturated methyl esters via the Wittig reaction
(2007) Letters in Organic Chemistry, 4 (6), pp. 384-387.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-36148930964&doi=10.2174%2f157017807781467650&partnerID=40&md5=0e35a03eee07d09c9d9e89e3abce7ed7

DOI: 10.2174/157017807781467650

Caballero, J., Fernández, L., Garriga, M., Abreu, J.I., Collina, S., Fernández, M.
Proteometric study of ghrelin receptor function variations upon mutations using amino acid sequence autocorrelation vectors and genetic algorithm-based least square support vector machines
(2007) Journal of Molecular Graphics and Modelling, 26 (1), pp. 166-178.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-34250845013&doi=10.1016%2fj.jmgm.2006.11.002&partnerID=40&md5=62b30d477108fabb008b747fce7d6273

DOI: 10.1016/j.jmgm.2006.11.002

Collina, S., Loddo, G., Urbano, M., Linati, L., Callegari, A., Ortuso, F., Alcaro, S., Laggner, C., Langer, T., Prezzavento, O., Ronsisvalle, G., Azzolina, O.
Design, synthesis, and SAR analysis of novel selective σ1 ligands
(2007) Bioorganic and Medicinal Chemistry, 15 (2), pp. 771-783.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33845315110&doi=10.1016%2fj.bmc.2006.10.048&partnerID=40&md5=9d588faeac8e4b3e8aecd5e98479b32d

DOI: 10.1016/j.bmc.2006.10.048

Caballero, J., Zampini, F.M., Collina, S., Fernández, M.
Quantitative structure-activity relationship modeling of growth hormone secretagogues agonist activity of some tetrahydroisoquinoline 1-carboxamides
(2007) Chemical Biology and Drug Design, 69 (1), pp. 48-55.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847106779&doi=10.1111%2fj.1747-0285.2007.00467.x&partnerID=40&md5=8c17eea13c177193bb322d9331459605

DOI: 10.1111/j.1747-0285.2007.00467.x

Brusotti, G., Habermann, J., Azzolina, O., Collina, S.
Preparation of arene carboxylic acids via a polymer-supported Kröhnke reaction
(2006) Letters in Organic Chemistry, 3 (12), pp. 943-947.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33846666649&doi=10.2174%2f157017806779468077&partnerID=40&md5=b885210d305935ad6f5b878a835bb821

DOI: 10.2174/157017806779468077

Azzolina, O., Collina, S., Urbano, M., Fata, E., Loddo, G., Linati, L., Lanza, E., Barbieri, A.
Highly diastereoselective synthesis of enantiopure naphthylaminoalcohols with analgesic properties
(2006) Chirality, 18 (10), pp. 841-848.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33750346270&doi=10.1002%2fchir.20328&partnerID=40&md5=89f577a330672aba541fd0c35de7b787

DOI: 10.1002/chir.20328

Martino, E., Ramaiola, I., Urbano, M., Bracco, F., Collina, S.
Microwave-assisted extraction of coumarin and related compounds from Melilotus officinalis (L.) Pallas as an alternative to Soxhlet and ultrasound-assisted extraction
(2006) Journal of Chromatography A, 1125 (2), pp. 147-151.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746859745&doi=10.1016%2fj.chroma.2006.05.032&partnerID=40&md5=3bc81c1b611666f90cddaa296d452c1c

DOI: 10.1016/j.chroma.2006.05.032

Azzolina, O., Collina, S., Rossi, D., Carnevale Baraglia, A., Alcaro, S., Artese, A.
High-throughput lipophilicity screening of opioid-like analgesics: Validation of computational methods by means of RP-HPLC analysis
(2006) Letters in Drug Design and Discovery, 3 (6), pp. 413-418.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33746750871&doi=10.2174%2f157018006777805530&partnerID=40&md5=1a0de8ce7ed069df03dcacbeaa1e90e1

DOI: 10.2174/157018006777805530

Collina, S., Loddo, G., Urbano, M., Rossi, D., Mamolo, M.G., Zampieri, D., Alcaro, S., Gallelli, A., Azzolina, O.
Enantioselective chromatography and absolute configuration of N,N-dimethyl-3-(naphthalen-2-yl)-butan-1-amines: Potential Sigma1 ligands
(2006) Chirality, 18 (4), pp. 245-253.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-33646244248&doi=10.1002%2fchir.20227&partnerID=40&md5=6ed48d38b8a019d6c7d9c9b0771638ef

DOI: 10.1002/chir.20227

Collina, S., Urbano, M., Magnani, A., Loddo, G., Azzolina, O.
Efficient microwave and phosphane-free synthesis of trisubstituted olefins via heck coupling
(2006) Letters in Organic Chemistry, 3 (1), pp. 16-20.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-34247247618&doi=10.2174%2f157017806774964549&partnerID=40&md5=27844e8fe739f2eed0e65bd658a6073f

DOI: 10.2174/157017806774964549

Collina, S., Rossi, D., Loddo, G., Barbieri, A., Lanza, E., Linati, L., Alcaro, S., Gallelli, A., Azzolina, O.
Chiral arylpyrrolidinols: Preparation and biological profile
(2005) Bioorganic and Medicinal Chemistry, 13 (9), pp. 3117-3126.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-16244392433&doi=10.1016%2fj.bmc.2005.02.054&partnerID=40&md5=0a7bc33603e97aeaf2ec47b3f1f7c6fa

DOI: 10.1016/j.bmc.2005.02.054

Collina, S., Loddo, G., Barbieri, A., Linati, L., Alcaro, S., Chimenti, P., Azzolina, O.
Microwave assisted synthesis of chiral pyrrolines with biological activity
(2004) Tetrahedron Asymmetry, 15 (22), pp. 3601-3608.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-8144223301&doi=10.1016%2fj.tetasy.2004.10.001&partnerID=40&md5=9e23ad9fe60624957540061ff0e0c9f5

DOI: 10.1016/j.tetasy.2004.10.001

Azzolina, O., Collina, S., Brusotti, G., Loddo, G., Linati, L., Lanza, E., Ghislandi, V.
Diastereoselective synthesis of chiral nonracemic naphthylaminoalcohols with analgesic activity
(2004) Tetrahedron Asymmetry, 15 (10), pp. 1651-1658.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-2342662124&doi=10.1016%2fj.tetasy.2004.03.036&partnerID=40&md5=8bd4a88037a0ce0fb41864298f01676f

DOI: 10.1016/j.tetasy.2004.03.036

Azzolina, O., Collina, S., Brusotti, G., Rossi, D., Linati, L., Lanza, E., Ghislandi, V.
Preparation of novel analgesics via diastereoselective nucleophilic addition to 1-dimethylamino-2-methylpentan-3-one
(2004) Tetrahedron Letters, 45 (7), pp. 1355-1357.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-1642578981&doi=10.1016%2fj.tetlet.2003.12.060&partnerID=40&md5=7c4c6918a35330e9d02d3cd4ac1eff21

DOI: 10.1016/j.tetlet.2003.12.060

Collina, S., Azzolina, O., Vercesi, D., Brusotti, G., Rossi, D., Barbieri, A., Lanza, E., Mennuni, L., Alcaro, S., Battaglia, D., Linati, L., Ghislandi, V.
Synthesis and pharmacological evaluation of new N-methyl-arylpyrrolidinols with analgesic activity
(2003) Farmaco, 58 (9), pp. 939-946.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0141788015&doi=10.1016%2fS0014-827X%2803%2900152-6&partnerID=40&md5=f4d6fc0be6e844c3d4fbdc52687e3172

DOI: 10.1016/S0014-827X(03)00152-6

Anzini, M., Canullo, L., Braile, C., Cappelli, A., Gallelli, A., Vomero, S., Menziani, M.C., De Benedetti, P.G., Rizzo, M., Collina, S., Azzolina, O., Sbacchi, M., Ghelardini, C., Galeotti, N.
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as κ-opioid receptor agonists endowed with antinociceptive and antiamnesic activity
(2003) Journal of Medicinal Chemistry, 46 (18), pp. 3853-3864.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0041927964&doi=10.1021%2fjm0307640&partnerID=40&md5=59770a96ec2bd3f4b9d3302707f77cbd

DOI: 10.1021/jm0307640

Azzolina, O., Collina, S., Brusotti, G., Rossi, D., Callegari, A., Linati, L., Barbieri, A., Ghislandi, V.
Chemical and biological profile of racemic and optically active dialkylaminoalkylnaphthalenes with analgesic activity
(2002) Tetrahedron Asymmetry, 13 (10), pp. 1073-1081.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037054305&doi=10.1016%2fS0957-4166%2802%2900241-0&partnerID=40&md5=f5ef6d0aa5130789047ae1bd2b2ae81e

DOI: 10.1016/S0957-4166(02)00241-0

Cappelli, A., Anzini, M., Vomero, S., Mennuni, L., Makovec, F., Doucet, E., Hamon, M., Menziani, M.Cristina, De Benedetti, P.G., Giorgi, G., Ghelardini, C., Collina, S.
Novel potent 5-HT3 receptor ligands based on the pyrrolidone structure: Synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities
(2002) Bioorganic and Medicinal Chemistry, 10 (3), pp. 779-801.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-18244384253&doi=10.1016%2fS0968-0896%2801%2900332-7&partnerID=40&md5=ae4cf377c2f96cce0e353ed9047ea7a2

DOI: 10.1016/S0968-0896(01)00332-7

Azzolina, O., Collina, S., Linati, L., Anzini, M., Cappelli, A., Scheideler, M.A., Sbacchi, M.
Enantiomers of 2-[(acylamino)ethyl]-1,4-benzodiazepines, potent ligands of κ-opioid receptor: Chiral chromatographic resolution, configurational assignment, and biological activity
(2001) Chirality, 13 (9), pp. 606-612.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034800577&doi=10.1002%2fchir.1185&partnerID=40&md5=3e5fe923a2058eb705d2e1a60740d1d3

DOI: 10.1002/chir.1185

Collina, S., Azzolina, O., Vercesi, D., Barbieri, A., Lanza, E., Linati, L., Ghislandi, V.
Synthesis of pyrrolinylnaphthalenes and evaluation of their antinociceptive activity
(2000) Farmaco, 55 (9-10), pp. 611-618.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034706935&doi=10.1016%2fS0014-827X%2800%2900078-1&partnerID=40&md5=82d3033e4685e772c5fe971bb5d01a2e

DOI: 10.1016/S0014-827X(00)00078-1

Collina, S., Azzolina, O., Vercesi, D., Sbacchi, M., Scheideler, M.A., Barbieri, A., Lanza, E., Ghislandi, V.
Synthesis and antinociceptive activity of pyrrolidinylnaphthalenes
(2000) Bioorganic and Medicinal Chemistry, 8 (8), pp. 1925-1930.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033859237&doi=10.1016%2fS0968-0896%2800%2900117-6&partnerID=40&md5=5b892b49221c2f7821e68a7321a7d933

DOI: 10.1016/S0968-0896(00)00117-6

Collina, S., Azzolina, O., Vercesi, D., Benevelli, F., Callegari, A., Tadini, C., Lanza, E., Barbieri, A., Ghislandi, V.
Dialkylaminoalkylnaphthalenes as novel opioid-like analgesics
(2000) Bioorganic and Medicinal Chemistry, 8 (4), pp. 769-775.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034071647&doi=10.1016%2fS0968-0896%2800%2900011-0&partnerID=40&md5=a189e623eb6740c8b64546373839af95

DOI: 10.1016/S0968-0896(00)00011-0

Collina, S., Benevelli, F., Vercesi, D., Ghislandi, V.
On the enantiomers of 2-dimethylamino-3-pentanone, key intermediates in the synthesis of analgesic alkylaminoalkylnaphthalenes
(1999) Tetrahedron Asymmetry, 10 (12), pp. 2387-2397.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033580766&doi=10.1016%2fS0957-4166%2899%2900223-2&partnerID=40&md5=a0b7236b7275297e9349838cad9a1c49

DOI: 10.1016/S0957-4166(99)00223-2

Ghislandi, V., Collina, S., Azzolina, O., Barbieri, A., Lanza, E., Tadini, C.
Preparation and configuration of racemic and optically active analgesic cycloaminoalkylnaphthalenes
(1999) Chirality, 11 (1), pp. 21-28.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032949697&doi=10.1002%2f%28SICI%291520-636X%281999%2911%3a1%3c21%3a%3aAID-CHIR4%3e3.0.CO%3b2-4&partnerID=40&md5=e0fc274fbb415aa65f8dbfe141b270a6

DOI: 10.1002/(SICI)1520-636X(1999)11:1<21::AID-CHIR4>3.0.CO;2-4

Azzolina, O., Dal Piaz, V., Collina, S., Giovannoni, M.P., Tadini, C.
Chiral resolution and absolute configuration of the enantiomers of 5- acetyl-2-methyl-4-methylsulfinyl-6-phenyl-3(2H)-pyridazinone and evaluation of their platelet aggregation inhibitory activity
(1997) Chirality, 9 (7), pp. 681-685.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030726247&doi=10.1002%2f%28SICI%291520-636X%281997%299%3a7%3c681%3a%3aAID-CHIR8%3e3.0.CO%3b2-A&partnerID=40&md5=b7f9f7410cb81518d78a8d4524f3ce66

DOI: 10.1002/(SICI)1520-636X(1997)9:7<681::AID-CHIR8>3.0.CO;2-A

Azzolina, O., Collina, S., Vercesi, D., Ghislandi, V., Bonabello, A., Galmozzi, M.R.
Chiral resolution, configurational study and pharmacological profile of 2-phenoxypropionic acids
(1997) Farmaco, 52 (6-7), pp. 449-456.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030690023&partnerID=40&md5=a18ffb7173f19a6cb9d03b77a8abaa88

Azzolina, O., Collina, S., Vercesi, D.
Stereoselective hydrolysis by esterase: A strategy for resolving 2-(R,R’-phenoxy)propionyl ester racemates
(1995) Farmaco, 50 (10), pp. 725-733.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029616466&partnerID=40&md5=06c4d9af18107f02951ace4edb152536

Azzolina, O., Collina, S.
Chiral recognition of alkyl 2-aryloxypropionates by HPLC
(1995) Journal of Liquid Chromatography, 18 (1), pp. 81-92.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028798726&doi=10.1080%2f10826079508009222&partnerID=40&md5=f8ad9bd6c3f38144a631695aa39423d0

DOI: 10.1080/10826079508009222

Azzolina, O., Vercesi, D., Collina, S., Ghislandi, V.
Chiral resolution of methyl 2-aryloxypropionates by biocatalytic stereospecific hydrolysis
(1995) Farmaco, 50 (4), pp. 221-226.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029048698&partnerID=40&md5=c4bb334a748d60ed9f8013235d46d355

Collina, S., Gamba, A., Ghislandi, V., Azzolina, O.
Preparation of (+)‐ and (−)‐1,2‐dimethyl‐3‐pyrrolidone and stability studies
(1995) Chirality, 7 (6), pp. 439-445.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028801406&doi=10.1002%2fchir.530070609&partnerID=40&md5=6c3471920c932169f6966dc4b5d873b0

DOI: 10.1002/chir.530070609

Ghislandi, V., Azzolina, O., Collina, S., Paroli, E., Antonilli, L., Giuseppetti, G., Tadini, C.
Preparation and configuration of racemic and optically active analgesic dialkylaminoalkylnaphthalenes
(1994) Chirality, 6 (5), pp. 389-399.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028064984&doi=10.1002%2fchir.530060506&partnerID=40&md5=09ec409c520ecfbfa536ba6647edc88d

DOI: 10.1002/chir.530060506

Azzolina, O., Collina, S., Ghislandi, V.
Optical resolution of aryloxypropionic acids and their esters by HPLC on cellulose tris-3,5-dimethyl-triphenylcarbamate derivative
(1993) Farmaco, 48 (10), pp. 1401-1416.
https://www.scopus.com/inward/record.uri?eid=2-s2.0-0027145157&partnerID=40&md5=1832a5f01e5fe09a434141ac3c1052df