The MedChem Lab Milestones
- Dr Roberta Listro wins the ACS prize for the best poster Elements for Future, SCI 2024
- Martina Garbagnoli and Roberta Listro win best Oral and Poster awards at P. Ehrlich MedChem 2024
- Federica Piaggi wins “Ing. Giacomo Bonaiuti” prize by Bracco Foundation
- Patent selected to participate to the Meet in Italy for Life Sciences brokerage event
- Dr Sara Salvi wins Premio di Laurea Oreste Pessina 2024
Latest Congress and dissemination
- Dr Roberta Listro wins the ACS prize for the best poster Elements for Future, SCI 2024
- 4th MMCS: Harnessing the Power of New Drug Modalities Part of the Molecules Medicinal Chemistry Symposium series
- 52°Congresso nazionale della società italiana di microbiologia, SIM 2024
- EFMC-ACSMEDI Medicinal Chemistry Frontiers 2024, Utrecht, Netherland
- Martina Garbagnoli and Roberta Listro win best Oral and Poster awards at P. Ehrlich MedChem 2024
- NBFC Events 2024
Publications
- From lichen to organoids: Usnic acid enantiomers show promise against Cholangiocarcinoma via MNK2 targeting and MAPK pathway modulationCavalloro, V.; Malacrida, A.; Miloso, M.; Ronchi, D.; Porta, A.; Fossati, A.; Gheza, G.; De Siervi, S.; Mantovani, S.; Oliviero, B.; Mondelli, M.U.; Pugliese, L.; Turato, C.; Martino, E.; Collina, S. (2025) Biomedicine and Pharmacotherapy DOI: 10.1016/j.biopha.2025.118208 ABSTRACT: Cholangiocarcinoma (CC) remains one of the most challenging biliary tract malignancies, with limited therapeutic options and poor survival rates. We report the discovery and mechanistic investigation of usnic acid (UA) enantiomers
- Vineyard pruning-wood waste valorisation: sustainable extraction of bioactive compoundsTumminelli, E.; Cavalloro, V.; Ingrà, C.; Ferrandino, A.; Porta, A.; Marrubini, G.; Martino, E., Rossi D.; Collina, S. (2025) Front. Chem., 13 1597833 DOI: 10.3389/fchem.2025.1597833 ABSTRACT: Introduction: The annual production of waste is expected to increase over the next forty years, representing one of the main challenges associated with the global rise in population. Consequently, the transition towards
- Essential Oils from Papaver rhoeas and Their Metabolomic Profiling.Cavalloro, V.; Robustelli della Cuna, F.S.; Malovini, A.; Villa, C.; Sottani, C.; Balestra, M.; Bracco, F.; Martino, E.; Collina, S. ((2024) Metabolites, 14, 664 DOI: 10.3390/metabo14120664 ABSTRACT: The Heck reaction is widely employed to build a variety of biologically relevant scaffolds and has been successfully implemented in the production of active pharmaceutical ingredients (APIs). Typically, the reaction with
- 1,3-Dithiolane as a Privileged Scaffold in Bioactive Derivatives: Chiral Resolution and Assignment of Absolute ConfigurationListro, R.; Rossino, G.; Cavalloro, V.; Rossi, D.; Boiocchi, M.; Robescu, M.S.; Bavaro, T.; Franchini, S.; Sorbi, C.; De Amici, M.; Linciano, P.; Collina, S. (2024) Int. J. Mol. Sci., 25, 12880 DOI: 10.3390/ijms252312880 ABSTRACT: The 1,3-dithiolane ring has been recently rehabilitated as a chemical scaffold in drug design. However, for derivatives that are substituted in position 4,
- Peptide Nucleic Acids in Saturation Transfer Difference Nuclear Magnetic Resonance Experiments: A Simple and Valuable Tool for Studying HuR–Small Molecule ComplexesGado, I.; Garbagnoli, M.; Ambrosio, F.A.; Listro, R.; Parafioriti, M.; Cauteruccio, S.; Rossi, D.; Linciano, P.; Costa, G.; Alcaro, S.; Vasile, F.; Collina,S. (2024) ACS Omega, 9(45) 45147–45158 DOI: 10.1021/acsomega.4c06244 ABSTRACT: Ribonucleic acid (RNA)-binding proteins (RBPs) play a key role in regulating RNA stability, fate, function, gene expression, post-transcriptional modifications, and cellular activities. Among the various RBPs